Lipoamide → Diglycerol 1,2-distearate

HRID 481270

Reaktionsgleichung

Reaktionsgleichung von HRID 481270
C1C(CCCCC(N)=O)SSC1.C(O)C(O)C[O:16][CH2:17][CH:18]([OH:21])[CH2:19][OH:20].[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>OCC(CO)O>[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].[OH:16][CH2:17][CH:18]([CH2:19][OH:20])[OH:21].[OH:16][CH2:17][CH:18]([CH2:19][OH:20])[OH:21]

Komponenten

5

Edukt 3

HCID 863LipoamideHCID 5281Stearic AcidHCID 42953Diglycerin

Produkt 1

HCID 131720779Diglycerol 1,2-distearateAusbeute 5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 753GlycerolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

heating to 70°C. Thereto were added 10 parts by weight of an immobilized lipase preparation (trade name: Lipozyme, IM20, mfd. by NOVO) composed of a lipase originating from Mucor miehei immobilized on an anion exchange resin and 29 parts by weight of linear diglycerol. Then the stearic acid was reacted with the linear glycerol under reduced pressure (2 torr) at 70° C. for 4 hours. The reaction product was filtered to eliminate the immobilized enzyme. The obtained filtrate was put in a continuous thin film distilling apparatus and distillation was carried out to eliminate unreacted stearic acid and diglycerol, and monoesters. The liquid thus obtained was subjected to silica gel column chromatography to eliminate triesters, thereby giving a diglycerol distearate mixture comprising diglycerol 1,6-distearate (about 50%), diglycerol 1,5-distearate (about 45%) and diglycerol 2,5-distearate (about 5%).

Aufarbeitung

  1. additionThereto were added 10 parts
  2. filtrationThe reaction product was filtered
  3. distillationdistilling
  4. distillationapparatus and distillation
  5. customThe liquid thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-a93092b2ff014c83bfa5ca7786229ba5
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789011

Verknüpfte Notizen

Wird geladen…