2-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine → 1-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)pyridin-2-yl]cyclopentane carboxylic acid ethyl ester

HRID 481403

Reaktionsgleichung

Reaktionsgleichung von HRID 481403
[CH2:1]([O:3][C:4]([C:6]1([C:11]2[CH:16]=[CH:15][C:14]([CH2:17]Br)=[CH:13][N:12]=2)[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH:19]1([C:22]2[NH:23][C:24]3[C:25]([N:32]=2)=[N:26][C:27]([CH3:31])=[CH:28][C:29]=3[CH3:30])[CH2:21][CH2:20]1>>[CH2:1]([O:3][C:4]([C:6]1([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][N:32]3[C:25]4=[N:26][C:27]([CH3:31])=[CH:28][C:29]([CH3:30])=[C:24]4[N:23]=[C:22]3[CH:19]3[CH2:21][CH2:20]3)=[CH:13][N:12]=2)[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 103134402-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridineHCID 701035861-(5-Bromomethylpyridin-2-yl)cyclopentanecarboxlic acid ethyl ester2×

Produkt 1

HCID 700869251-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)pyridin-2-yl]cyclopentane carboxylic acid ethyl ester

Versuchsvorschrift

The product of Example 10, Step 3, above (45), was alkylated as described in Example 1, Step 5, using 2-cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridine (13) to produce the title compound (48).

Quellen und Nachweise

ORD-Eintrag
ord-d9823b0750f84d649baf30be4e65a122
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789415

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