Azobisisobutyronitrile → (6-Bromomethylnaphthalen-2-yl)acetic acid ethyl ester

HRID 481405Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 481405
[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH3:16])[CH:12]=2)[CH:7]=1)[CH3:2].C1C(=O)N([Br:25])C(=O)C1.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:16][Br:25])[CH:12]=2)[CH:7]=1)[CH3:2]

Komponenten

5

Edukt 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 58186771(6-Methylnaphthalen-2-yl)acetic acid ethyl ester2×

Produkt 1

HCID 54418685(6-Bromomethylnaphthalen-2-yl)acetic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Reaktionsbedingungen

Temperatur
82 °C

Versuchsvorschrift

To a solution of the product of Step 1, above (50) (3.07 mmol), in 6 ml of CCl4 was added NBS (3.07 mmol) and azobisisobutyronitrile (0.09 mmol) and the mixture was heated to 82° C. for 2 hours. The reaction was cooled to ambient temperature and filtered through celite, washing the cake thoroughly with CCl4. The organics were then concentrated to dryness to obtain the title compound (51).

Aufarbeitung

  1. temperatureThe reaction was cooled to ambient temperature
  2. filtrationfiltered through celite
  3. washwashing the cake thoroughly with CCl4
  4. concentrationThe organics were then concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-7c2e3c76889c447593dedd3e50b9ea2a
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789415

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