1-(5-Bromomethylpyridin-2-yl)cyclopentanecarboxlic acid ethyl ester → 2-butyl-3-[6-(1-ethoxycarbonylcyclopentyl)pyridin-3-ylmethyl]-5-chloro-3H-imidazole-4-carboxylic acid ethyl ester

HRID 481418Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 481418
[CH2:1]([O:3][C:4]([C:6]1([C:11]2[CH:16]=[CH:15][C:14]([CH2:17]Br)=[CH:13][N:12]=2)[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH2:19]([O:21][C:22]([C:24]1[NH:25][C:26]([CH2:30][CH2:31][CH2:32][CH3:33])=[N:27][C:28]=1[Cl:29])=[O:23])[CH3:20]>>[CH2:19]([O:21][C:22]([C:24]1[N:25]([CH2:17][C:14]2[CH:13]=[N:12][C:11]([C:6]3([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:10][CH2:9][CH2:8][CH2:7]3)=[CH:16][CH:15]=2)[C:26]([CH2:30][CH2:31][CH2:32][CH3:33])=[N:27][C:28]=1[Cl:29])=[O:23])[CH3:20]

Komponenten

3

Edukt 2

HCID 701035861-(5-Bromomethylpyridin-2-yl)cyclopentanecarboxlic acid ethyl esterHCID 178441690HCID 178441690, Verbindung

Produkt 1

HCID 700890892-butyl-3-[6-(1-ethoxycarbonylcyclopentyl)pyridin-3-ylmethyl]-5-chloro-3H-imidazole-4-carboxylic acid ethyl ester

Versuchsvorschrift

Alkylation was carried out on 1-(5-bromomethylpyridin-2-yl)cyclopentane-carboxlic acid ethyl ester (45) as described in Example 1, Step 5, using 2-butyl-5-chloro-3H-imidazole-4-carboxylic acid ethyl ester (69) to produce the title compound (82).

Quellen und Nachweise

ORD-Eintrag
ord-ce966d1f17ca4368af99a40dedb47453
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789415

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