Ethyl isocyanatoacetate → 8-(3-ethoxycarbonylmethylureido)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one

HRID 481452Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 481452
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]2[C:7]3[NH:8][C:9](=[O:15])[C:10]4[N:11]([CH:12]=[CH:13][N:14]=4)[C:6]=3[CH2:5][C:4]=2[CH:3]=1.[N:19]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:20]=[O:21]>CN(C)C=O>[CH2:26]([O:25][C:23]([CH2:22][NH:19][C:20](=[O:21])[NH:1][C:2]1[CH:18]=[CH:17][C:16]2[C:7]3[NH:8][C:9](=[O:15])[C:10]4[N:11]([CH:12]=[CH:13][N:14]=4)[C:6]=3[CH2:5][C:4]=2[CH:3]=1)=[O:24])[CH3:27]

Komponenten

4

Edukt 2

HCID 76283Ethyl isocyanatoacetateHCID 189753948-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one

Produkt 1

HCID 190660338-(3-ethoxycarbonylmethylureido)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The preparation is carried out as in Example 7, from 3 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one and 2 times 2.8 ml of ethyl 2-isocyanatoacetate in 170 ml of dimethylformamide. The insoluble material thus obtained is filtered and recrystallized from dimethylformamide. After filtration, washing with water and drying under reduced pressure (1 mm Hg, 0.13 kPa) at 60° C., there are obtained 2.6 g of 8-(3-ethoxycarbonylmethylureido)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of a pink solid, the melting point of which is greater than 260° C. (Analysis C18H17N5 O4.0.75H2O.0.20DMF, % calculated C: 58.85, H: 4.66, N: 19.06, % found C: 58.9, H: 5.0, N: 18.9).

Aufarbeitung

  1. customThe insoluble material thus obtained
  2. filtrationis filtered
  3. customrecrystallized from dimethylformamide
  4. filtrationAfter filtration
  5. washwashing with water
  6. customdrying under reduced pressure (1 mm Hg, 0.13 kPa) at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-62ba3847281f4d51bde9784d112e1af8
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05789406

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