Hydroxyphenylacetic acid → Benzeneacetic acid, 4-hydroxy-, methyl ester

HRID 48146

Reaktionsgleichung

Reaktionsgleichung von HRID 48146
Cl.[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][C:6]1[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=1

Komponenten

4

Edukt 3

HCID 127Hydroxyphenylacetic acidHCID 313Hydrochloric AcidHCID 887Methanol

Produkt 1

HCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

Versuchsvorschrift

Hydrogen chloride was bubbled through a solution of (4-hydroxyphenyl) acetic acid (25 g, 0.16 mole) in methanol (100 ml) at room temperature. An exotherm resulted in the solution refluxing for about 10 minutes. The mixture was allowed to cool to room temperature and the solvent was evaporated in vacuo to afford methyl(4-hydroxyphenyl)acetate as a yellow oil (27.5 g) which crystallised on seeding, m.p. 46-52° C.

Aufarbeitung

  1. customAn exotherm resulted in the solution
  2. temperaturerefluxing for about 10 minutes
  3. customthe solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-123330c67b6b4ba3a55b2d817c1c4a56
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703347B2

Verknüpfte Notizen

Wird geladen…