8-Bromo-1,2,3,4-tetrahydro-2-methyl-6-nitro-5-isoquinolinamine → 8-Bromo-1,2,3,4-tetrahydro-2-methyl-5,6-isoquinolinediamine

HRID 48204Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 48204
[Br:1][C:2]1[C:11]2[CH2:10][N:9]([CH3:12])[CH2:8][CH2:7][C:6]=2[C:5]([NH2:13])=[C:4]([N+:14]([O-])=O)[CH:3]=1>C1COCC1.[Ni]>[Br:1][C:2]1[CH:3]=[C:4]([NH2:14])[C:5]([NH2:13])=[C:6]2[C:11]=1[CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2

Komponenten

4

Edukt 1

HCID 100168198-Bromo-1,2,3,4-tetrahydro-2-methyl-6-nitro-5-isoquinolinamine

Produkt 1

HCID 103550328-Bromo-1,2,3,4-tetrahydro-2-methyl-5,6-isoquinolinediamineAusbeute 90,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of the product from Example 10 (0.78 g, 2.73 mmol) in 100 mL of THF was treated with Raney nickel (1.0 g) and hydrogenated for 1.5 hours at room temperature. The reaction mixture was filtered and concentrated to give the title compound as a tan solid (0.63 g, 90%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-173703b7c60b4c998a0161a33606f342
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703391B2

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