1-Naphthylamine → (6,7-Dimethoxy-quinazolin-4-yl)-alpha-naphthalenylamine

HRID 482246

Reaktionsgleichung

Reaktionsgleichung von HRID 482246
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1>CCO>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][N:3]=[C:2]2[NH:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1

Komponenten

4

Edukt 2

HCID 86401-NaphthylamineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

Produkt 1

HCID 18770835(6,7-Dimethoxy-quinazolin-4-yl)-alpha-naphthalenylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a 25 mL flask with 10 ml of abs. EtOH is added 0.137 g of 4-chloro-6,7-dimethoxyquinazoline and 0.087 g of 1-aminonaphthalene. The solution is heated to reflux whereupon the insoluble materials dissolve. After 5 minutes at reflux a precipatate forms. The solution is allowed to stir an additional 10 min before cooling and isolation of the product as the hydrochloride salt by simple filtration. High-vacuum drying of the solid provided analytically pure (6,7-dimethoxy-quinazolin-4-yl)-alpha-naphthalenylamine (0.142 g, white powder, m.p. 271°-273° C.

Aufarbeitung

  1. temperatureThe solution is heated
  2. temperatureto reflux whereupon the insoluble materials
  3. dissolutiondissolve
  4. temperatureAfter 5 minutes at reflux a precipatate forms
  5. temperaturebefore cooling
  6. filtrationisolation of the product as the hydrochloride salt by simple filtration
  7. customHigh-vacuum drying of the solid

Quellen und Nachweise

ORD-Eintrag
ord-6e389f9582b8477284db9136dc404aea
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05795889

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