Isatoic Anhydride → Anthranilate dATP

HRID 482378

Reaktionsgleichung

[CH:1]1[N:6]=[C:5]2[N:7]([C@@H:10]3[O:14][C@H:13]([CH2:15][O:16][P:17]([O:20][P:21]([O:24][P:25]([OH:28])([OH:27])=[O:26])([OH:23])=[O:22])([OH:19])=[O:18])[C@@H:12]([OH:29])[CH2:11]3)[CH:8]=[N:9][C:4]2=[C:3]([NH2:30])[N:2]=1.[C:31]12[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=1)[NH:36]C(=O)[O:34][C:32]2=[O:33].C([O-])(=O)C1C(=CC=CC=1)N.P(OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1O)(OP(OP(O)(O)=O)(O)=O)(=O)O>>[C:32]([O-:34])(=[O:33])[C:31]1[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=1)[NH2:36].[CH:1]1[N:6]=[C:5]2[N:7]([C@@H:10]3[O:14][C@H:13]([CH2:15][O:16][P:17]([O:20][P:21]([O:24][P:25]([OH:28])([OH:27])=[O:26])([OH:23])=[O:22])([OH:19])=[O:18])[C@@H:12]([OH:29])[CH2:11]3)[CH:8]=[N:9][C:4]2=[C:3]([NH2:30])[N:2]=1

Komponenten

Edukt 3

HCID 8359Isatoic Anhydride

HCID 15993Datp

HCID 86753040anthranilate ATP

Produkt 1

HCID 86753039Anthranilate dATPAusbeute 80 %

Versuchsvorschrift

Anthranilate dATP was prepared from dATP and isatoic anhydride by a procedure similar to that described by Hiratsuka {T. Hiratsuka (1982) J. Biol. Chem 257, pp. 13354-13358} for the synthesis of the anthranilate ATP and was purified by chromatography on Lichroprep RP18 (25-40 μm) using 1 mM triethylammonium acetate as eluent.

Aufarbeitung

customwas purified by chromatography on Lichroprep RP18 (25-40 μm)

Quellen und Nachweise

ORD-Eintrag: ord-f17dd989498c491281d5152dc0ae99eb
Quelldatensatz: uspto-grants-1998_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05798210

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