Hydrogen Peroxide → HCID 178476844, Verbindung

Diethyl 4-[N-(2-cyanophenyl)carbamoyl]benzylphosphonate (11.2 g) was dissolved in 100 ml of THF and cooled with ice water. After adding 50 ml of a 30% hydrogen peroxide aqueous solution containing 1.2 g of sodium hydroxide dropwise, the reaction mixture was stirred at room temperature for 16 hours. Saturated brine (50 ml) was added, and the reaction mixture was extracted with chloroform. The chloroform layer was dried over magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was dissolved in 150 ml of ethanol and 20 ml of a 2N sodium hydroxide solution and stirred at room temperature for 6 hours. Saturated brine (150 ml) was added, and the reaction mixture was extracted with chloroform. The chloroform layer was dried over magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was recrystallized with methylene chloride-diethyl ether to give 5.9 g of diethyl 4-(4-hydroxyquinazolin-2-yl)benzylphosphonate as colorless crystals.

1. extractionthe reaction mixture was extracted with chloroform
2. dry with materialThe chloroform layer was dried over magnesium sulfate
3. distillationthe solvent was distilled off under reduced pressure
4. dissolutionThe residue was dissolved in 150 ml of ethanol
5. stirring20 ml of a 2N sodium hydroxide solution and stirred at room temperature for 6 hours
6. additionSaturated brine (150 ml) was added
7. extractionthe reaction mixture was extracted with chloroform
8. dry with materialThe chloroform layer was dried over magnesium sulfate
9. distillationthe solvent was distilled off under reduced pressure
10. customThe residue was recrystallized with methylene chloride-diethyl ether

ORD-Eintrag

ord-d5568d12ef1242a6b07d99407bf7fd13

Quelldatensatz

uspto-grants-1998_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05798344