Methyl chloroformate → 2-(N-methyl-N-(methoxycarbonyl)amino)-4'-difluoromethoxyacetophenone
Reaktionsgleichung
[CH3:1][N:2](C)[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([F:15])[F:14])=[CH:8][CH:7]=1)=[O:5].Cl[C:18]([O:20][CH3:21])=[O:19]>>[CH3:1][N:2]([CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([F:14])[F:15])=[CH:8][CH:7]=1)=[O:5])[C:18]([O:20][CH3:21])=[O:19]Komponenten
3
Versuchsvorschrift
By substantially following the procedure of Example 115b using 16.8 g (73 mmole) of 2-dimethylamino-4'-difluoromethoxy-acetophenone Example 126c and 7.6 g (81 mmole) of methyl chloroformate one obtain 12 g of 2-(N-methyl-N-(methoxycarbonyl)amino)-4'-difluoromethoxyacetophenone an oil. bp 150°-190° C. at 0.7 torr.
Quellen und Nachweise
- ORD-Eintrag
- ord-90da2f8471534951819adb6563093ab8
- Quelldatensatz
- uspto-grants-1998_08
- DOI