Diketene → 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate

HRID 483192Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 483192
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH2:7]([N:14]([CH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])[CH3:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1C=CC=CC=1>[C:4]([O:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][N:14]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:15])(=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

Komponenten

4

Edukt 2

HCID 12661DiketeneHCID 13422168HCID 13422168, Verbindung

Produkt 1

HCID 101083403-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

One gram of diketen was added dropwise to a stirred solution of 3-(N-benzyl-N-methylamino)-2,2-dimethyl propanol in 1 ml of benzene at 70° C. Sturing was continued for 1.5 hours at 70° C. after the addition. The solvent was distilled off to leave an oily residue. The residue was chromatographed over silica gel to afford 2.8 g of desired 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate (oily substance).

Aufarbeitung

  1. additionafter the addition
  2. distillationThe solvent was distilled off
  3. customto leave an oily residue
  4. customThe residue was chromatographed over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-9bf57e4daab84dd3bbcec133d8830958
Quelldatensatz
uspto-grants-1986_03
Patentnummer
US04578395

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