2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepine-5(4H)-one → 2-[(dimethylamino)methyl]2,3-dihydro-4-methylpyrido[3,2-f][1,4]oxazepin-5(4H)-one

HRID 4832

Reaktionsgleichung

Reaktionsgleichung von HRID 4832
Cl[CH2:2][CH:3]1[CH2:9][N:8]([CH3:10])[C:7](=[O:11])[C:6]2[CH:12]=[CH:13][CH:14]=[N:15][C:5]=2[O:4]1.ClCCC1[CH2:25][N:24](C)[C:23](=O)C2C=CC=NC=2O1>>[CH3:23][N:24]([CH2:2][CH:3]1[CH2:9][N:8]([CH3:10])[C:7](=[O:11])[C:6]2[CH:12]=[CH:13][CH:14]=[N:15][C:5]=2[O:4]1)[CH3:25]

Komponenten

3

Edukt 2

HCID 137264362-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepine-5(4H)-oneHCID 212715882-chloromethyl-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepin-5(4H)-one

Produkt 1

HCID 136894292-[(dimethylamino)methyl]2,3-dihydro-4-methylpyrido[3,2-f][1,4]oxazepin-5(4H)-one

Versuchsvorschrift

When in the procedure of Example 10, 2-chloromethyl-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepin-5(4H)-one is substituted for 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepin-5(4H)-one, the title compound is prepared and is isolated if desired as a pharmaceutically acceptable salt.

Aufarbeitung

  1. customis isolated

Quellen und Nachweise

ORD-Eintrag
ord-f2ced41ca80546fca5cc841a48e387ac
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04727152

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