Hydrochloric Acid → 4-nitro- DL-Phenylalanine, methyl ester, monohydrochloride

HRID 483386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 483386
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@@H:9]([C:11]([OH:13])=[O:12])[NH2:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:16].[CH3:17]O>>[ClH:16].[NH2:10][CH:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:15][CH:14]=1)[C:11]([O:13][CH3:17])=[O:12]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 137064-Nitro-3-phenyl-L-alanine

Produkt 1

HCID 533959764-nitro- DL-Phenylalanine, methyl ester, monohydrochloride

Versuchsvorschrift

A solution of p-nitro-L-phenylalanine (12.6 g) and c.HCl (7.5 g) in methanol (150 ml) was refluxed for 1.5 hours and the solvent then evaporated in vacuo. The residue was triturated with ether and recrystallised from SVM to give the desired product as a off-white solid, [α]25 +15.3° (c=0.55, MeOH).

Aufarbeitung

  1. customthe solvent then evaporated in vacuo
  2. customThe residue was triturated with ether
  3. customrecrystallised from SVM

Quellen und Nachweise

ORD-Eintrag
ord-71a8162ecd834347b161bb44eb91ad7d
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05225431

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