[4-(Propan-2-yl)phenyl]hydrazine hydrochloride → MK 886
Reaktionsgleichung
[ClH:1].[CH:2]([C:5]1[CH:10]=[CH:9][C:8]([NH:11]N)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[CH3:13][C:14]([CH3:28])([CH2:19][C:20](=O)[CH2:21][S:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:15]([O:17]C)=[O:16]>>[Cl:1][C:8]1[CH:9]=[CH:10][C:5]([CH2:2][N:11]2[C:8]3[C:7](=[CH:6][C:5]([CH:2]([CH3:4])[CH3:3])=[CH:10][CH:9]=3)[C:21]([S:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[C:20]2[CH2:19][C:14]([CH3:28])([CH3:13])[C:15]([OH:17])=[O:16])=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
Following the procedure of Example 10, but using 1-(p-chlorobenzyl)-1[-(4-(i-propyl)phenyl]hydrazine hydrochloride and methyl 2,2-dimethyl-5-(t-butylthio)-4-oxopentanoate as starting materials and hydrolysis at reflux, the title compound was prepared, mp 189°-192°.
Aufarbeitung
- custommaterials and hydrolysis
- temperatureat reflux
Quellen und Nachweise
- ORD-Eintrag