StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Potassium Carbonate → 3,4-Dimethyl-7-(2-methyl-1,3,4-thiadiazol-5-yl)-methoxycoumarin

HRID 483814
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 483814
O[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:14])=[C:7]([CH3:13])[C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.Cl[CH2:16][C:17]1[S:18][C:19](C)=[N:20][N:21]=1.[C:23]([O-])([O-])=[O:24].[K+].[K+]>CC(C)=O>[CH3:13][C:7]1[C:8](=[O:12])[O:9][C:10]2[C:5]([C:6]=1[CH3:14])=[C:4]([O:24][CH3:23])[CH:3]=[C:2]([C:19]1[S:18][C:17]([CH3:16])=[N:21][N:20]=1)[CH:11]=2
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 54129907-hydroxy-3,4-dimethyl-2H-chromen-2-oneHCID 155820072-(Chloromethyl)-5-methyl-1,3,4-thiadiazole

Produkt 1

HCID 197514973,4-Dimethyl-7-(2-methyl-1,3,4-thiadiazol-5-yl)-methoxycoumarin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 5.0 g of 7-hydroxy-3,4-dimethylcoumarin, 3.9 g of 2-chloromethyl-5-methyl-1,3,4-thiadiazole, 3.5 g of K2CO3 and 100 ml of acetone was refluxed for 20 hours and evaporated down, and the residue was partitioned in H2O/methylene chloride. After the undissolved constituents had been separated off, the organic phase was washed once with 1 N NaOH and then with H2O, dried over Na2SO4 and evaporated down, and the residue was recrystallized from methanol and dried.

Aufarbeitung

  1. temperaturewas refluxed for 20 hours
  2. customevaporated down
  3. customthe residue was partitioned in H2O/methylene chloride
  4. customAfter the undissolved constituents had been separated off
  5. washthe organic phase was washed once with 1 N NaOH
  6. dry with materialwith H2O, dried over Na2SO4
  7. customevaporated down
  8. customthe residue was recrystallized from methanol
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5ab5e7b7ac174bcea2d68ce47b9005b7
Quelldatensatz
uspto-grants-1993_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05227392

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion