Hexane → 4-(3-t-Butylureidomethyl)-1-aminomethylbenzene

HRID 483925

Reaktionsgleichung

Reaktionsgleichung von HRID 483925
[C:1]1([CH2:9][NH2:10])[CH:6]=[CH:5][C:4]([CH2:7][NH2:8])=[CH:3][CH:2]=1.CCCCCC.[C:17]([N:21]=[C:22]=[O:23])([CH3:20])([CH3:19])[CH3:18]>C(Cl)Cl>[C:17]([NH:21][C:22](=[O:23])[NH:8][CH2:7][C:4]1[CH:5]=[CH:6][C:1]([CH2:9][NH2:10])=[CH:2][CH:3]=1)([CH3:20])([CH3:19])[CH3:18]

Komponenten

5

Edukt 3

HCID 8058HexaneHCID 62412tert-Butyl isocyanateHCID 683151,4-Benzenedimethanamine

Produkt 1

HCID 200967404-(3-t-Butylureidomethyl)-1-aminomethylbenzeneAusbeute 42,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2.7 g p-xylylenediamine in 100 ml methylene dichloride, was added slowly with stirring 10 ml of a n-hexan solution containing 990 mg t-butyl isocyanate under ice cooling. Stirring was continued at room temperature for two hours, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography, giving 1 g of 4-(3-t-butylureidomethyl)-1-aminomethylbenzene.

Aufarbeitung

  1. distillationthe solvent was distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ed4449f4d3c24a34ad09ba7e4296ac68
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05227492

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