2-Aminoindane → 4-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidine

HRID 48398

Reaktionsgleichung

Reaktionsgleichung von HRID 48398
Cl[C:2]1[C:3]2[C:10]([CH3:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1>C(O)C>[CH2:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:21][CH:13]1[NH:12][C:2]1[C:3]2[C:10]([CH3:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1

Komponenten

4

Edukt 2

HCID 763102-AminoindaneHCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidine

Produkt 1

HCID 99257354-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidineAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4-chloro-5-methylthieno[2,3-d]pyrimidine (92 mg, 0.50 mmol) (see J. Pharm. Soc. JAPAN, 109, 464 (1989)) and 2-aminoindan (330 mg, 2.5 mmol) in dry ethanol (1 ml) were heated to reflux under an argon atmosphere for 40 minutes. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (hexane:ethyl acetate=5:1) to obtain the title compound (140 mg, 0.50 mmol) having the following physical properties:

Aufarbeitung

  1. temperatureto reflux under an argon atmosphere for 40 minutes
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe residue obtained
  4. customwas purified by silica gel chromatography (hexane:ethyl acetate=5:1)

Quellen und Nachweise

ORD-Eintrag
ord-2dd1b64c46964b598edb3b42f0923799
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703421B1

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