Potassium Carbonate → 1-(2-Benzothiazolyl)-4-piperidinemethanol

HRID 484060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 484060
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Cl[C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[S:11]1[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=[C:10]1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][OH:1])[CH2:4][CH2:5]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 119872-ChlorobenzothiazoleHCID 4207714-Piperidinemethanol

Produkt 1

HCID 197495981-(2-Benzothiazolyl)-4-piperidinemethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

30 g of 4-hydroxymethylpiperidine, 44 g of 2-chlorobenzothiazole and 72 g of potassium carbonate are reacted in 600 ml of acetonitrile under reflux overnight. After filtration and evaporation of the solvent, the residue is taken up in 200 ml of ethyl acetate and extracted with 1N hydrochloric acid. The aqueous phase is made alkaline with caustic soda and extracted with dichloromethane. The expected product is obtained by drying and evaporation.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. filtrationAfter filtration and evaporation of the solvent
  3. extractionextracted with 1N hydrochloric acid
  4. extractionextracted with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-dbea2f4798a04c9585a5415e578b8940
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05229398

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