Potassium Carbonate → 1-(Benzimidazol-2-yl)-4-aminomethylpiperidine

HRID 484061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 484061
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

Produkt 1

HCID 197495451-(Benzimidazol-2-yl)-4-aminomethylpiperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

45 g of 4-aminomethylpiperidine are placed in 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

Aufarbeitung

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

Quellen und Nachweise

ORD-Eintrag
ord-be580a30a9b34f9bbed5e1bf558fbc35
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05229399

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