Potassium Carbonate → 1-(2-Benzothiazolyl)-4-piperidinemethanol

HRID 484064Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 484064
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Cl[C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[S:11]1[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=[C:10]1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][OH:1])[CH2:4][CH2:5]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 119872-ChlorobenzothiazoleHCID 4207714-Piperidinemethanol

Produkt 1

HCID 197495981-(2-Benzothiazolyl)-4-piperidinemethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

30 g of 4-hydroxymethylpiperidine, 44 g of 2-chlorobenzothiazole and 72 g of potassium carbonate are reacted in 600 ml of acetonitrile under reflux overnight. After filtration and evaporation of the solvent, the residue is taken up in 200 ml of ethyl acetate and extracted with 1 N hydrochloric acid. The aqueous phase is made alkaline with caustic soda and extracted with dichloromethane. The expected product is obtained by drying and evaporation.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. filtrationAfter filtration and evaporation of the solvent
  3. extractionextracted with 1 N hydrochloric acid
  4. extractionextracted with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-250f6729c0fa49de9efe3da788efbe95
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05229399

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