HCID 19380545, Verbindung → HCID 178513639, Verbindung

HRID 484272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 484272
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1>[Pt].C.O1CCOCC1.C(N(CC)CC)C>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:15]=[CH:16][C:17]([C:18]([NH2:20])=[O:19])=[CH:21][CH:22]=2)[CH2:10][CH2:9]1

Komponenten

4

Edukt 1

HCID 19380545HCID 19380545, Verbindung

Produkt 1

HCID 178513639HCID 178513639, VerbindungAusbeute 45,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 16218561HCID 16218561, VerbindungKatalysatorHCID 68453242Dioxan triethylamineLösungsmittel

Versuchsvorschrift

A mixture of 500 mg of 4-[4-[2-(1,3-dioxolan-2-yl)-ethylidene]cyclohexyl]benzamide and 20 ml of dioxan/triethylamine (vol. 9:1) was hydrogenated by means of 500 mg of 10 percent platinum-charcoal for 2 hours. The reaction mixture was then filtered and the filtrate was evaporated. Recrystallization of the evaporation residue from 40 ml of dioxan gave 230 mg of 4-[trans-4-[2-(1,3-dioxolan-2-yl)ethyl]cyclohexyl]benzamide as colorless crystals.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated
  3. customRecrystallization of the evaporation residue from 40 ml of dioxan

Quellen und Nachweise

ORD-Eintrag
ord-cc12e6272ee146b49d030add2b098a0f
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05230826

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