Triethylamine → N-Benzyl-2-(5-methylthieno[2,3-d]pyrimidine-4-yl)amino-5-indan Carboxamide

HRID 48433

Reaktionsgleichung

Reaktionsgleichung von HRID 48433
Cl.[CH2:2]([NH:9][C:10]([C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][CH:16]([NH2:21])[CH2:15]2)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(CC)CC)C.Cl[C:30]1[C:31]2[C:38]([CH3:39])=[CH:37][S:36][C:32]=2[N:33]=[CH:34][N:35]=1>C(O)C>[CH2:2]([NH:9][C:10]([C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][CH:16]([NH:21][C:30]1[C:31]3[C:38]([CH3:39])=[CH:37][S:36][C:32]=3[N:33]=[CH:34][N:35]=1)[CH2:15]2)=[O:11])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 22719605N-benzyl-2-amino-5-indan carboxamide hydrochloride

Produkt 1

HCID 12094070N-Benzyl-2-(5-methylthieno[2,3-d]pyrimidine-4-yl)amino-5-indan CarboxamideAusbeute 63,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Using N-benzyl-2-amino-5-indan carboxamide hydrochloride (660 mg, 2.2 mmol), ethanol (19 ml), triethylamine (0.94 ml, 6.7 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (410 mg, 2.2 mmol), a similar procedure to b) in Production Example 208 was carried out. A solid obtained by purifying the product by silica gel chromatography (methylene chloride:ethanol=95:5) was washed with ether to obtain the title compound (580 mg, 1.4 mmol) having the following physical properties:

Aufarbeitung

  1. customA solid obtained
  2. customby purifying the product by silica gel chromatography (methylene chloride:ethanol=95:5)
  3. washwas washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-8406a96542af420f8f8d78d9e6ce3e44
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703421B1

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