Phosphorus tribromide → (5-Bromopentyl)benzene

HRID 484337

Reaktionsgleichung

Reaktionsgleichung von HRID 484337
P(Br)(Br)[Br:2].[C:5]1([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]O)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(Cl)(Cl)Cl>[C:5]1([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][Br:2])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromide2×HCID 615235-Phenyl-1-pentanol

Produkt 1

HCID 285561(5-Bromopentyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A 1.8 g (6.7 mmol) amount of phosphorus tribromide was added to a chloroform solution (20 ml) of 3.3 g (20 mmol) of 5-phenyl-1-pentanol and the resulting solution was heated at reflux for 4 hours. When the reaction was traced by TLC, the starting materials were found to still remain in the reaction mixture, and so 0.2 g of phosphorus tribromide was further added and heated at reflux. Afterwards, the reaction solution was washed with water and dried with anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. Thus, 4.30 g of a crude 5-phenylpentyl bromide was obtained.

Aufarbeitung

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for 4 hours
  3. additionwas further added
  4. temperatureheated
  5. temperatureat reflux
  6. washAfterwards, the reaction solution was washed with water
  7. dry with materialdried with anhydrous magnesium sulfate
  8. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-37c2e7860e4e4a2284712f3d40aed8d0
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05231105

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