Triethylamine → 2-[5-Methylthieno[2,3-d]pyrimidine-4-yl]aminoindan-5-carboxylic Acid Morpholinamide

HRID 48436

Reaktionsgleichung

Reaktionsgleichung von HRID 48436
Cl.[N:2]1([C:8]([NH2:10])=[O:9])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[NH2:11][CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:21]([OH:23])=[O:22])[CH:18]=2)[CH2:13]1.C(N(CC)CC)C.Cl[C:32]1[C:33]2[C:40]([CH3:41])=[CH:39][S:38][C:34]=2[N:35]=[CH:36][N:37]=1>C(O)C>[N:2]1([C:8]([NH2:10])=[O:9])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[CH3:41][C:40]1[C:33]2[C:32]([NH:11][CH:12]3[CH2:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:21]([OH:23])=[O:22])[CH:18]=4)[CH2:13]3)=[N:37][CH:36]=[N:35][C:34]=2[S:38][CH:39]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 698498462-Aminoindan-5-carboxylic acid morpholinamide hydrochloride

Produkt 1

HCID 1317243672-[5-Methylthieno[2,3-d]pyrimidine-4-yl]aminoindan-5-carboxylic Acid MorpholinamideAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Using 2-aminoindan-5-carboxylic acid morpholinamide hydrochloride (750 mg, 2.7 mmol), ethanol (23 ml), triethylamine (1.1 ml, 8.2 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (500 mg, 2.7 mmol), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (methylene chloride:methanol=95:5) to yield a fraction, which was then washed with ether to obtain the title compound (680 mg, 1.7 mmol) having the following physical properties:

Aufarbeitung

  1. customThe product obtained
  2. customwas purified by silica gel chromatography (methylene chloride:methanol=95:5)
  3. customto yield a fraction, which
  4. washwas then washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-809fdd9988a440ba8ee2240257153fb3
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703421B1

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