1-Propanesulfonyl chloride, 2-methyl- → 2-Methyl-propane-1-sulfonic acid 6-(2,4-diamino-pyrimidin-5-ylmethyl)-1-methyl-1H-indol-4-yl ester

HRID 48459Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 48459
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([OH:20])[C:13]3[CH:14]=[CH:15][N:16]([CH3:19])[C:17]=3[CH:18]=2)=[CH:4][N:3]=1.[CH3:21][CH:22]([CH3:28])[CH2:23][S:24](Cl)(=[O:26])=[O:25]>>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[CH:18]=[C:17]3[C:13]([CH:14]=[CH:15][N:16]3[CH3:19])=[C:12]([O:20][S:24]([CH2:23][CH:22]([CH3:28])[CH3:21])(=[O:26])=[O:25])[CH:11]=2)=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 1822361-Propanesulfonyl chloride, 2-methyl-HCID 227428906-(2,4-Diamino-pyrimidin-5-ylmethyl)-1-methyl-1H-indol-4-ol

Produkt 1

HCID 865885712-Methyl-propane-1-sulfonic acid 6-(2,4-diamino-pyrimidin-5-ylmethyl)-1-methyl-1H-indol-4-yl ester

Versuchsvorschrift

This compound was produced by reaction of 6-(2,4-diamino-pyrimidin-5-ylmethyl)-1-methyl-1H-indol-4-ol (Example 4,269 mg, 1.00 mmol) with 2-methylpropane-1-sulfonyl chloride (188 mg, 1.20 mmol), following the procedure detailed in Example 5c. Yield: 58 mg (15%). White solid.

Quellen und Nachweise

ORD-Eintrag
ord-61a43b6f644d4704a679f4c56d95a96d
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703397B2

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