Chloroform → 4-Hexadecyloxyphenoxyacetic acid methyl ester

HRID 484610Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 484610
[CH2:1]([O:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].Br[CH2:26][C:27]([O:29][CH3:30])=[O:28].C(=O)([O-])[O-].[K+].[K+].C(Cl)(Cl)Cl>CC(C)=O>[CH3:30][O:29][C:27](=[O:28])[CH2:26][O:24][C:21]1[CH:22]=[CH:23][C:18]([O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:19][CH:20]=1

Komponenten

6

Edukt 4

HCID 6212ChloroformHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 43779374-(Hexadecyloxy)phenol

Produkt 1

HCID 102507944-Hexadecyloxyphenoxyacetic acid methyl esterAusbeute 89,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 23 g of p-(hexadecyloxy)phenol, 13.35 g of methyl bromoacetate, 10.45 g of potassium carbonate in 200 ml of acetone is refluxed for 24 hours. The mixture is cooled, chloroform added and filtered. The filtrate is evaporated and the residue crystallized from hexane to give 25 g of the desired compound as a gray white solid.

Aufarbeitung

  1. temperatureis refluxed for 24 hours
  2. temperatureThe mixture is cooled
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. customthe residue crystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-49d5cdd1004248a6a9170d775d28b15e
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05231182

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