4-Fluorobenzoyl chloride → N-(4-fluorobenzoyl)isobutyrylmethylamine

HRID 485021Notizen

Reaktionsgleichung

Cl.[C:2]([CH2:7][NH2:8])(=[O:6])[CH:3]([CH3:5])[CH3:4].C(=O)(O)[O-].[Na+].[F:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:8][CH2:7][C:2](=[O:6])[CH:3]([CH3:5])[CH3:4])=[O:20])=[CH:17][CH:16]=1

Komponenten

Edukt 3

HCID 678794-Fluorobenzoyl chloride

HCID 516892Sodium Bicarbonate

HCID 134017361-Amino-3-methylbutan-2-one hydrochloride

Produkt 1

HCID 13490306N-(4-fluorobenzoyl)isobutyrylmethylamineAusbeute 89,4 %

Versuchsvorschrift

4.0 g of isobutyrylmethylamine hydrochloride, 6.1 g of sodium bicarbonate and 5.1 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(4). 5.8 g of N-(4-fluorobenzoyl)isobutyrylmethylamine are thereby obtained. Yield: 89.2%.

Aufarbeitung

customas described in Preparation 1-(4)

Quellen und Nachweise

ORD-Eintrag: ord-2b415b9ba8c64dc1b48f47c9afb60913
Quelldatensatz: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04535089

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