4-Amino-2-methylpyrimidine-5-carbaldehyde → 4-Amino-2-methyl-5-pyrimidinemethanamine

HRID 485482

Reaktionsgleichung

Reaktionsgleichung von HRID 485482
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH:9]=O)=[CH:4][N:3]=1.[NH3:11].CO>O[Mo](O)(=O)=O>[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][NH2:11])=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 129047264-Amino-2-methylpyrimidine-5-carbaldehydeHCID 21705897Ammonia methanol

Produkt 1

HCID 667624-Amino-2-methyl-5-pyrimidinemethanamineAusbeute 93,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 82208Molybdic acidKatalysator

Versuchsvorschrift

Into an Erlenmeyer's flask of 100 ml, 2.00 g (14.6 millimole) of 2-methyl-4-amino-5-formylpyrimidine, 40 g of 20 wt. % ammonia-methanol solution and 2.0 mg of molybdic acid (H2MoO4.H2O) were added, and the mixture was stirred for 2 hours under room temperature, with the flask being closely stoppered. Following subsequently the same procedure as in Example 1, 2-methyl-4-amino-5-aminomethylpyrimidine was obtained at a yield of 93.5%.

Quellen und Nachweise

ORD-Eintrag
ord-c829ba66a22041189243bf237dd00d53
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04536577

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