HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Acid → Nandrolone Decanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | Decanoic Acid | HCID 2969 | — |
| Edukt | Nandrolone | HCID 9904 | — |
| Edukt | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Katalysator | p-Toluenesulfonic acid | HCID 6101 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Methanol--water (1/1) | HCID 22242641 | — |
| Produkt | Nandrolone Decanoate | HCID 9677 | 88,8% |
Reaktionsschritte
To a stirred solution of 5,48 g 19-nortestosterone, 4 g decanoic acid, 0.24 g DMAP and 0.19 g pTSA in 35 ml CH2Cl2 is slowly added at 10° C. a solution of 5.6 g DCC in 30 ml CH2Cl2. After 5 h at room temperature 2 ml acetic acid is added. The same work-up procedure as in Example 6 gives 7.6 g of pure 19-nortestosterone decanoate (88% yield) as white crystals from methanol/water. M.P. 35°-36° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04537722 |
| Quelldatensatz | uspto-grants-1985_08 |
| ORD ID | ord-a747324c27494f3e9207531db3365d42 |
| Quellennotiz | uspto-grants-1985_08 |