HCID 20239805, Verbindung → HCID 13281197, Verbindung

HRID 485803Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 485803
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[CH:3][CH:2]=1>C(O)C.[Ni]>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[NH:12][CH:11]=[CH:10][N:9]=2)=[CH:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 20239805HCID 20239805, Verbindung

Produkt 1

HCID 13281197HCID 13281197, VerbindungAusbeute 62,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
210 °C

Versuchsvorschrift

The mixture of 2-(4-pyridylmethyl)-imidazoline (6.6 g, 0.04M) and Raney-Nickle (3 g) was heated initially at 210° C. and gradually raised to 250° C. in 15 min. After the reaction, the reaction was dissolved in ethanol (50 ml) and filtered to remove the catalyst. The filtrate was stripped to dryness and distilled (0.25 mmHg, 180° C.) to give 2-(4-pyridylmethyl)-imidazole (4.1 g, 62% yield).

Aufarbeitung

  1. temperaturegradually raised to 250° C. in 15 min
  2. customAfter the reaction
  3. filtrationfiltered
  4. customto remove the catalyst
  5. distillationdistilled (0.25 mmHg, 180° C.)

Quellen und Nachweise

ORD-Eintrag
ord-f276b56b55574833897326deeafc4cb3
Quelldatensatz
uspto-grants-1985_08
Patentnummer
US04537969

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