Hydrochloric Acid → FK1052 hydrochloride

HRID 486189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 486189
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12.[ClH:23]>CO.C(O)C>[ClH:23].[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 125368FK 1052

Produkt 1

HCID 9949384FK1052 hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittel2×HCID 887MethanolLösungsmittel

Versuchsvorschrift

The suspension of 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one (2.0 g) in methanol (60 ml) was treated with hydrogen chloride in ethanol and then diluted with hot aqueous ethanol (water:ethanol, 1:4) to give a clear solution. After filtration of the insoluble materials, the filtrate was evaporated under reduced pressure to about 40 ml and allowed to stand at room temperature overnight. Filtration, followed by washing with ethanol, gave 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one hydrochloride (2.10 g) as crystals.

Aufarbeitung

  1. customto give a clear solution
  2. filtrationAfter filtration of the insoluble materials
  3. customthe filtrate was evaporated under reduced pressure to about 40 ml
  4. filtrationFiltration
  5. washby washing with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ce7ea70b3a9840f984da19c53a88fc39
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05290785

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