2-Methylthiomethyl-3,4,6-trifluoroaniline → 3,4,6-Trifluoro-2-methylaniline

HRID 486252

Reaktionsgleichung

Reaktionsgleichung von HRID 486252
CS[CH2:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:5]=1[NH2:6]>[Ni].C(O)C>[CH3:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:5]=1[NH2:6]

Komponenten

4

Edukt 1

HCID 189744612-Methylthiomethyl-3,4,6-trifluoroaniline

Produkt 1

HCID 226251783,4,6-Trifluoro-2-methylanilineAusbeute 71,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

Aufarbeitung

  1. filtrationAfter the catalyst is filtered off
  2. additionthe filtrate is added with water
  3. extractionextracted with dichloromethane
  4. dry with materialThe is dried over magnesium sulfate
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-65a42f8c16c84334b479a3ff0c9274d7
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05290934

Verknüpfte Notizen

Wird geladen…