Acetyl chloride → 1-(2,4-Dimethoxyphenyl)ethanone

HRID 486422

Reaktionsgleichung

Reaktionsgleichung von HRID 486422
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.[C:11](Cl)(=[O:13])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH3:10])[CH:6]=[CH:7][C:8]=1[C:11](=[O:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 90251,3-DimethoxybenzeneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 700161-(2,4-Dimethoxyphenyl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Using a Perrier modification, Perrier, Chem. Ber., Vol. 33, pp. 819 et seq. (1900), and Perrier, Bull. Soc. Chim. France, pp. 859 et seq. (1904), 1,3-dimethoxybenzene (138.0 g) (which may be obtained from Aldrich Chemical Company, Inc., Milwaukee, Wis.) is reacted with acetyl chloride (72.0 g), methylene chloride (500 ml), and aluminum chloride (145.0 g) to provide 2',4'-dimethoxy-acetophenone, which may then be purified using standard vacuum fractional distillation.

Quellen und Nachweise

ORD-Eintrag
ord-ba47e44c9a6a4cb5a071b3c192b07bc6
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05292719

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