Ammonium Carbonate → HCID 19095882, Verbindung
Reaktionsgleichung
[C:1]([C:4]1([CH2:17][C:18]([OH:20])=O)[CH2:16][CH2:15][N:7]2[C:8]3[C:13]([CH:14]=[C:6]2[CH2:5]1)=[CH:12][CH:11]=[CH:10][CH:9]=3)(O)=[O:2].C(=O)([O-])[O-].[NH4+:25].[NH4+]>ClCCl.CO>[NH:25]1[C:18](=[O:20])[CH2:17][C:4]2([CH2:16][CH2:15][N:7]3[C:8]4[C:13]([CH:14]=[C:6]3[CH2:5]2)=[CH:12][CH:11]=[CH:10][CH:9]=4)[C:1]1=[O:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 200 °C
Versuchsvorschrift
A mixture of 100 mg of 8-carboxy-6,7,8,9-tetrahydropyrido[1,2-a]indole-8-acetic acid and 69 mg of ammonium carbonate was heated at 200° C. for 1 hour. After cooling and chromatography on silica gel using dichloromethane/methanol (9:1) for the elution there were obtained 64 mg of 7,9-dihydrospiro[pyrido[1,2-a]indole-8(6H),3'-pyrrolidine]-2',5'-dione.