Piperidine → 1-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

HRID 487163Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487163
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15](F)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(=O)([O-])O.[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 100841181-Acetyl-4-(4-fluorobenzoylmethyl)piperidine

Produkt 1

HCID 193909281-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 516892Sodium BicarbonateLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture consisting of 1.84 g of 1-acetyl-4-(4-fluorobenzoylmethyl)piperidine and 5 ml of piperidine was stirred under heating at 100° C. for 20 hours. After completion of the reaction, the reaction mixture was diluted with a saturated aqueous solution of sodium hydrogen carbonate and extracted with ethyl acetate. After drying, the solvent was ditilled off and the oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate) to give 2.2 g of a pale yellow oil.

Aufarbeitung

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. customAfter drying
  4. customthe oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-b07a53c531c14b9eac21ba8f5bc91767
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05294625

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