Thionyl Chloride → 2-Methyl-2-(3-thienyl) propionic acid chloride
Reaktionsgleichung
[CH3:1][C:2]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)([CH3:6])[C:3](O)=[O:4].S(Cl)([Cl:14])=O>C(Cl)(Cl)Cl>[CH3:1][C:2]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)([CH3:6])[C:3]([Cl:14])=[O:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The 2-methyl-2-(3-thienyl)propionic acid (34.0 g); obtained in Example 8, was dissolved in chloroform (60 ml) and to this solution was added thionyl chloride (31.0 g), followed by a 30 minute-refluxing under heating. After the reaction, the solvent and remaining thionyl chloride was removed under reduced pressure. The remaining crude product was distilled under reduced pressure to obtain 2-methyl-2-(3-thienyl) propionic acid chloride with bp 86°-88° C./2.Otorr.
Aufarbeitung
- customobtained in Example 8
- temperature-refluxing
- temperatureunder heating
- customAfter the reaction
- customwas removed under reduced pressure
- distillationThe remaining crude product was distilled under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-bf8e0204c9b448d0ba2e7a2f9d01c6c3
- Quelldatensatz
- uspto-grants-1994_03
- Patentnummer
- US05296454
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