Thionyl Chloride → 2-(3-Thienyl)propionic acid chloride

HRID 487535Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487535
[S:1]1[CH:5]=[CH:4][C:3]([CH:6]([CH3:10])[C:7](O)=[O:8])=[CH:2]1.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[S:1]1[CH:5]=[CH:4][C:3]([CH:6]([CH3:10])[C:7]([Cl:13])=[O:8])=[CH:2]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 131348672-(Thiophen-3-yl)propanoic acid

Produkt 1

HCID 218341522-(3-Thienyl)propionic acid chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The 2-(3-thienyl)propionic acid (22.9 g) was dissolved in chloroform (60 ml), to which was added thionyl chloride (20 g), followed by 30 minutes refluxing. The reaction was carried out in a similar manner to the foregoing Example 9 to obtain 2-(3-thienyl)propionic acid chloride with bp 76°-78° C./2.0 torr.

Aufarbeitung

  1. temperaturerefluxing

Quellen und Nachweise

ORD-Eintrag
ord-38c575b82ab44d9ab1beab35d1ac6ef0
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05296454

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