4-Tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole → 4-Tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole

HRID 487704Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487704
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([C:26]([O:28]CC)=[O:27])[C:21]([O:23]CC)=[O:22])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>Cl>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([C:21]([OH:23])=[O:22])[C:26]([OH:28])=[O:27])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 1

HCID 190926974-Tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole

Produkt 1

HCID 190927654-Tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazoleAusbeute 27,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A mixture of 4-tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole (3.99 g) and conc. hydrochloric acid (20 ml) was stirred under reflux for 6 hours. After being cooled, the resulting mixture was extracted with ethyl acetate. The extract was allowed to stand until there were no further precipitates separated out. The precipitates were collected by filtration and washed with ethyl acetate to give 4-tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole (0.96 g).

Aufarbeitung

  1. temperatureunder reflux for 6 hours
  2. temperatureAfter being cooled
  3. extractionthe resulting mixture was extracted with ethyl acetate
  4. customno further precipitates
  5. customseparated out
  6. filtrationThe precipitates were collected by filtration
  7. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-79e832f0fa3b43a795750c260e9bf939
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05296495

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