Hydrochloric Acid → HCID 19093039, Verbindung

HRID 487725Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487725
[ClH:1].C([N:5]1[CH2:10][CH2:9][C:8]2[S:11][C:12]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([NH2:14])[C:7]=2[CH2:6]1)(=O)C>CO>[ClH:1].[NH2:14][C:13]1[C:7]2[CH2:6][NH:5][CH2:10][CH2:9][C:8]=2[S:11][C:12]=1[C:15]([O:17][CH3:18])=[O:16]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 19093041HCID 19093041, Verbindung

Produkt 1

HCID 19093039HCID 19093039, VerbindungAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

20 ml of methanol and then 5.1 ml of concentrated hydrochloric acid were added to 2.54 g of methyl 5-acetyl-3-amino-4,5,6,7tetrahydrothieno[3,2-c]pyridine-2-carboxylate (Compound No. 16) obtained in Example 1. The resultant mixture was heated under reflux for 4 hours. After cooling, the crystals thus formed were taken by filtration to obtain 1.70 g (68%) of methyl 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate hydrochloride.

Aufarbeitung

  1. custom16) obtained in Example 1
  2. temperatureunder reflux for 4 hours
  3. temperatureAfter cooling
  4. customthe crystals thus formed
  5. filtrationwere taken by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a0bc80d4251f45c3b78165ddbb33391a
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05296603

Notizen zur Reaktion

Wird geladen…