Hydrochloric Acid → 2-Oxo-1,3-thiazolidine-5-carboxylic acid

HRID 487976Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 487976
[OH-:1].[Na+].Cl.[NH2:4][CH2:5][CH:6]([S:10][C:11](CC1C=CC=CC=1)=S)[C:7]([OH:9])=[O:8].Cl>C(O)C>[O:1]=[C:11]1[NH:4][CH2:5][CH:6]([C:7]([OH:9])=[O:8])[S:10]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86747702HCID 86747702, Verbindung

Produkt 1

HCID 189610442-Oxo-1,3-thiazolidine-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

12.0 ml of a 1 N aqueous solution of sodium hydroxide were added to a suspension of 1.2 g of 3-amino-2-(benzylthiocarbonylthio)propionic acid hydrochloride in 35 ml of ethanol, and the resulting mixture was stirred at room temperature for 30 minutes, after which 12.0 ml of 1 N aqueous hydrochloric acid were added, whilst ice-cooling. The solvent was then removed by distillation under reduced pressure, the resulting residue was dissolved in diethyl ether and the solution was dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, to give 0.50 g of a colorless powder. This powder was recrystallized from ethyl acetate, to give 0.25 g of the title compound as colorless columnar crystals, melting at 148°-150° C.

Aufarbeitung

  1. temperaturecooling
  2. customThe solvent was then removed by distillation under reduced pressure
  3. dissolutionthe resulting residue was dissolved in diethyl ether
  4. dry with materialthe solution was dried over anhydrous magnesium sulfate
  5. customThe solvent was then removed by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3e5df2a8b7094439bdbf5641b1aaf4dc
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05298516

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