Sodium Hydroxide → 3-Hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoic acid

HRID 488152Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 488152
[OH:1][CH:2]([CH2:8][CH2:9][CH:10]=[C:11]([CH3:23])[CH2:12][CH2:13][CH:14]=[C:15]([CH3:22])[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20])[CH2:3][C:4]([O:6]C)=[O:5].[OH-].[Na+]>C(O)C>[OH:1][CH:2]([CH2:8][CH2:9][CH:10]=[C:11]([CH3:23])[CH2:12][CH2:13][CH:14]=[C:15]([CH3:22])[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20])[CH2:3][C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 53652710Methyl 3-hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoate

Produkt 1

HCID 537523723-Hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of methyl 3-hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoate (139 mg, 430 μmol), ethanol (1 mL) and sodium hydroxide (1N, 440 μL, 440 μmol) was stirred at room temperature for two hours. The crude mixture was purified by flash chromatography on a 20 mm ID silica gel column. Elution of the column with choloform:acetic acid (40:1/v=v) gave title compound as a colorless gum.

Aufarbeitung

  1. customThe crude mixture was purified by flash chromatography on a 20 mm ID silica gel column
  2. washElution of the column with choloform

Quellen und Nachweise

ORD-Eintrag
ord-38b575bca1d94ac9b544ec23065db09a
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05298655

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