Dodecanoyl chloride → HCID 131718374, Verbindung

HRID 488205Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 488205
[C:1](Cl)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].NC[C:17]1[CH:18]=[C:19]([Si:22]([CH2:27][CH3:28])([CH2:25][CH3:26])[CH2:23][CH3:24])[O:20][CH:21]=1.[CH2:29]([N:31](CC)CC)C>O1CCCC1>[C:1]([NH:31][CH2:29][C:18]1[CH:17]=[CH:21][O:20][C:19]=1[Si:22]([CH2:23][CH3:24])([CH2:25][CH3:26])[CH2:27][CH3:28])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Komponenten

5

Edukt 3

HCID 8166Dodecanoyl chlorideHCID 8471TriethylamineHCID 150370494-Aminomethyl-2-triethylsilylfuran2×

Produkt 1

HCID 131718374HCID 131718374, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Dodecanoyl chloride (109 mg, 0.49 mmol) was added to a solution of 4-aminomethyl-2-triethylsilylfuran (Compound 2, 70 mg, 0.33 mmol) and triethylamine (69 microliter, 0.49 mmol) in tetrahydrofuran (3 ml) at room temperature. After stirring at room temperature overnight (ca. 15 hours), most of the solvent was evaporated and the residue was purified by chromatography on preparative silica thin layer plates (developed with 50% ethyl ether/hexane) to give the title amide as a colorless oil.

Aufarbeitung

  1. custommost of the solvent was evaporated
  2. customthe residue was purified by chromatography on preparative silica thin layer plates (developed with 50% ethyl ether/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-13ae9ee1bc2c4129a9c2ab2514fad63b
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05298633

Notizen zur Reaktion

Wird geladen…