Hydrochloric Acid → Ethyl 6-(methylamino)-3-pyridazinecarboxylate

HRID 488461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 488461
[CH3:1][NH:2][C:3]1[N:4]=[N:5][C:6]([C:9]([OH:11])=[O:10])=[CH:7][CH:8]=1.Cl.[CH2:13](O)[CH3:14]>>[CH3:1][NH:2][C:3]1[N:4]=[N:5][C:6]([C:9]([O:11][CH2:13][CH3:14])=[O:10])=[CH:7][CH:8]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 222714356-(Methylamino)pyridazine-3-carboxylic Acid

Produkt 1

HCID 22271465Ethyl 6-(methylamino)-3-pyridazinecarboxylate

Versuchsvorschrift

A solution of 3-methylaminopyridazine-6-carboxylic acid (0.58 g) in ethanol (50 ml) was saturated with HCl gas, refluxed 48 hours and evaporated. The residue was partitioned between EtOAc and aqueous NaHCO3, separated and the aqueous re-extracted with EtOAc. The organic was dried and evaporated to give title compound (0.61 g). MS(+ve ion chemical ionisation) m/z 182 (MH+, 100%).

Aufarbeitung

  1. temperaturerefluxed 48 hours
  2. customevaporated
  3. customThe residue was partitioned between EtOAc and aqueous NaHCO3
  4. customseparated
  5. extractionthe aqueous re-extracted with EtOAc
  6. customThe organic was dried
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-a04624f73001438ab890b608c3aae5d7
Quelldatensatz
uspto-grants-2005_12
Patentnummer
US06972297B2

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