Diethylamine → 4-[(Diethylamino)methyl]benzoic acid

HRID 488541

Reaktionsgleichung

Reaktionsgleichung von HRID 488541
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>C(#N)C>[CH2:12]([N:14]([CH2:15][CH3:16])[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)[CH3:13]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 742344-(Chloromethyl)benzoic acid

Produkt 1

HCID 9485164-[(Diethylamino)methyl]benzoic acidAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

1 g (1 equivalent) of α-chloroparatoluic acid and 1.22 mL (2 equivalents) of diethylamine are placed in solution in 30 mL of acetonitrile. The reaction mixture is taken to reflux for 48 hours. The solvent is evaporated off under vacuum and the residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40 then pure MeOH). The product is obtained in the form of a white powder after precipitation from hexane. (Yield=63%).

Aufarbeitung

  1. temperatureto reflux for 48 hours
  2. customThe solvent is evaporated off under vacuum
  3. customthe residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40
  4. customThe product is obtained in the form of a white powder
  5. customafter precipitation from hexane

Quellen und Nachweise

ORD-Eintrag
ord-67b3606ed97745088224a32eb7d53c20
Quelldatensatz
uspto-grants-2005_12
Patentnummer
US06972343B1

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