Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate → Trifluoroacetic acid

HRID 488658

Reaktionsgleichung

Reaktionsgleichung von HRID 488658
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[C:15]=1[C:16]([O:18][CH3:19])=[O:17])=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].ClCCl>>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[C:15]=1[C:16]([O:18][CH3:19])=[O:17].[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]

Komponenten

4

Edukt 2

HCID 10980693Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoateHCID 21863450Trifluoroacetic acid methylene chloride

Produkt 2

HCID 6422Trifluoroacetic acidHCID 11832643Methyl 2-(4-aminobutoxy)-6-hydroxybenzoate

Versuchsvorschrift

Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate (410 mg, 1.2 mmol) was treated with trifluoroacetic acid/dichloromethane (6 mL, 1:1/v:v) at ambient temperature for 3 hours, concentrated under reduced pressure and evaporated with acetonitrile twice to provide the titled amine as its trifluoroacetic acid salt (450 mg).

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. customevaporated with acetonitrile twice

Quellen und Nachweise

ORD-Eintrag
ord-568236dc42d244379cbec0ebfbe7e366
Quelldatensatz
uspto-grants-2005_12
Patentnummer
US06972340B2

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