Hydrochloric Acid → Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoate

HRID 488682

Reaktionsgleichung

Reaktionsgleichung von HRID 488682
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[C:15]([C:28]([O:30][CH3:31])=[O:29])=[C:16]([O:24]COC)[C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2)=O)(C)(C)C.Cl>O1CCOCC1>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[C:15]([C:28]([O:30][CH3:31])=[O:29])=[C:16]([OH:24])[C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22271972Methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoate

Produkt 1

HCID 22271969Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoateAusbeute 102,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a mixture of methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoate (28 mg, 0.064 mmol) was added 4M HCl in dioxane (1 mL). The mixture was stirred at ambient temperature for 30 minutes, concentrated under reduced pressure to provide the titled compound (19 mg, 100%) as its hydrochloride salt.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5eae51615e85413895203e397774bdcf
Quelldatensatz
uspto-grants-2005_12
Patentnummer
US06972340B2

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