HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Oxalyl chloride → 2-Chloro-4-fluoro-5-nitrobenzoyl chloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Oxalyl chloride | HCID 65578 | — |
| Edukt | 2-Chloro-4-fluoro-5-nitrobenzoic Acid | HCID 7210828 | — |
| Katalysator | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | 1,2-Dichloroethane | HCID 11 | — |
| Produkt | 2-Chloro-4-fluoro-5-nitrobenzoyl chloride | HCID 15124384 | — |
Reaktionsschritte
A mixture of 2-chloro-4-fluoro-5-nitrobenzoic acid (50.0 g, 0.228 mol) and N,N-dimethylformamide (5 drops) in 1,2-dichloroethane is treated dropwise with oxalyl chloride (30.8 mL, 0.353 mol), refluxed for 3 hours, cooled, and concentrated in vacuo to obtain the title product as an orange solid which is identified by NMR spectral analysis.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06706663B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-77741e50a88d4d9fb0e0a54fbf5403c2 |
| Quellennotiz | uspto-grants-2004_03 |