HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 2-Chloro-4-fluorophenol | HCID 74814 | — |
| Edukt | 5-(Chloromethyl)-3-(prop-2-en-1-yl)-1,2,4-oxadiazole | HCID 19797130 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole | HCID 19797129 | 80,8% |
Reaktionsschritte
0.71 g of 2-chloro-4-fluorophenol, 0.77 g of 3-allyl-5-chloromethyl-1,2,4-oxadiazole and 0.83 of potassium carbonate were added to 20 ml of acetone. After completion of the reaction, the resulting precipitates were filtered out from the mixture and then acetone was removed by distillation, and the residue was purified by column chromatography (benzene:hexane=1:1) to obtain 1.05 g of the desired product(yield: 80.8%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05242890 |
| Quelldatensatz | uspto-grants-1993_09 |
| ORD ID | ord-78085214e0d5496ab614bdad6a715709 |
| Quellennotiz | uspto-grants-1993_09 |