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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 4896Erstellt: 23. Oktober 2026

Potassium Carbonate → 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole

https://huagongshe.com/de/reaction/4896

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktPotassium CarbonateHCID 11430—
Edukt2-Chloro-4-fluorophenolHCID 74814—
Edukt5-(Chloromethyl)-3-(prop-2-en-1-yl)-1,2,4-oxadiazoleHCID 19797130—
LösungsmittelAcetoneHCID 180—
Produkt3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazoleHCID 1979712980,8%

Reaktionsschritte

0.71 g of 2-chloro-4-fluorophenol, 0.77 g of 3-allyl-5-chloromethyl-1,2,4-oxadiazole and 0.83 of potassium carbonate were added to 20 ml of acetone. After completion of the reaction, the resulting precipitates were filtered out from the mixture and then acetone was removed by distillation, and the residue was purified by column chromatography (benzene:hexane=1:1) to obtain 1.05 g of the desired product(yield: 80.8%).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS05242890
Quelldatensatzuspto-grants-1993_09
ORD IDord-78085214e0d5496ab614bdad6a715709
Quellennotizuspto-grants-1993_09