Hydrochloric Acid → 1,2-Benzisothiazole-3-carboxylic acid

HRID 48990Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 48990
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10](N)=[O:11])=[N:2]1.[OH-:13].[Na+].Cl>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10]([OH:11])=[O:13])=[N:2]1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 156394701,2-Benzothiazole-3-carboxamide

Produkt 1

HCID 945121,2-Benzisothiazole-3-carboxylic acidAusbeute 96 %

Versuchsvorschrift

A mixture of 1,2-benzisothiazole-3-carboxamide (5.0 g, 0.028 mole) and 1N aqueous sodium hydroxide (55 ml) is heated on a steam bath until solution is achieved (approximately 30 minutes), cooled to room temperature, and acidified with 2N hydrochloric acid. The resulting precipitate is filtered and dried in vacuo to afford the title compound (1.85 g, 96%) as a white solid, which is identified by NMR and IR spectral analysis.

Aufarbeitung

  1. temperatureis heated on a steam bath until solution
  2. custom(approximately 30 minutes)
  3. filtrationThe resulting precipitate is filtered
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-799d51a894f9464c914a010d58fc72da
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06706663B2

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